Newest Win 10 21H2 Update Issues?

We are about to push out a company wide 21H2 update. We tested it out, but we have too many different makes and models of Window 10 machines out there to test them all.

Has anyone run into any issues with it?

Nope, you should be good to go. It is the chrome browser updates that we have only had an issue with, and even then, not that often.